Sergiy Stakhovsky was the defending champion, but lost to Julien Benneteau in the quarterfinals. John Isner defeated Benneteau in the final, 4–6, 6–3, 6–4.

Seeds

All seeds received a bye into the second round.

Qualifying

Draw

Key

Finals

Top half

Section 1

Section 2

Bottom half

Section 3

Section 4

References

  • Main Draw

Winston Salem Open 2022 Men's Singles Draw Preview and Prediction

WinstonSalem Open ProAm • Western Wake Tennis Association

WinstonSalem Open 2021 Men's Singles Draw Preview, Analysis and

WinstonSalem Open 2013 Daily Scores, Results and Schedule News

Murray to continue singles comeback at WinstonSalem Open Tennis Majors